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At Ingenes, we are proud to share that we will soon welcome two renowned scientists from the University of Oregon, world leaders in gene therapy and reproductive biotechnology. One of the most exciting advances of this collaboration is the consolidation of IVF MORE® (Magnetic Ovulatory Restoration), a cutting-edge procedure aimed at improving egg quality and increasing your chances of success with assisted reproduction. What does the visit from the experts of Oregon Health & Science University bring? During their stay at Ingenes, we will have: Dr. Shoukhrat Mitalipov, Head of Gene Therapy and Embryonic Cells, pioneer in reproductive biotechnology. Dr. Nuria Martí-Gutiérrez, specialist in genetics and advanced embryology. Together they will carry out the first ovarian restoration session at Ingenes, a key step in offering solutions to those who have had IVF cycles with poor egg quality. How does IVF MORE® enhance egg quality? These researchers have developed techniques such as nuclear transfer, mitochondrial replacement therapy and embryonic stem cell reprogramming. Thanks to this boost, Ingenes continues offering more effective alternatives to those who previously could only opt for egg donation. Learn more details at Scientists from Oregon Health & Science University will visit Ingenes to drive advances in fertility and IVF MORE®. The importance of a state-of-the-art laboratory At Ingenes we have launched a laboratory equipped with cutting-edge technology for diagnosis, restoration and optimization of reproductive cells, reinforcing our leadership in fertility in Latin America. Discover more about The Vital Role of the Laboratory in the In Vitro Fertilization Process at Ingenes. 20 years transforming lives In 2025 we celebrate two decades of experience in assisted reproduction, always with the most advanced technology and human team. If you are looking to improve your fertility and increase your chances of pregnancy, IVF MORE® could be the alternative you have been waiting for. Avoid self-medicating and always consult a Fertility specialist. Frequently Asked Questions about the scientists’ visit and the IVF MORE® technique 1. What does mitochondrial replacement therapy contribute to ovarian restoration? It consists of transferring healthy mitochondria to eggs with dysfunction, improving energy production (ATP) and promoting eggs with greater embryonic division capacity. It is key in cases of implantation failure or advanced maternal age. Always consult with an Assisted Reproduction specialist before making any decision. 2. What does IVF MORE® consist of and who can benefit? IVF MORE® uses low-intensity magnetic fields and growth factors to stimulate ovarian microcirculation. 1–5 mL of biochemical mediators are administered to help improve egg quality. It is ideal for women with low ovarian reserve, history of failed IVF or poor egg quality. A specialist will determine if you are a candidate after hormonal and ultrasound studies. 3. Why does a cutting-edge laboratory make a difference? Modern laboratories feature incubators with precise CO₂ and O₂ control, high-resolution microscopes and nanoliter microinjection systems. This ensures optimal conditions for handling eggs and embryos, raising fertilization rates. At Ingenes we operate with ISO certifications and daily quality controls to provide you with the confidence you need. 4. What is Ingenes’s experience in advanced assisted reproduction? With more than 15,000 IVF cycles performed and protocols such as IVF MORE®, nuclear transfer and embryonic stem cell reprogramming, our multidisciplinary team offers you a personalized plan based on genetic, hormonal and anatomical assessments. Avoid self-medicating and always consult a specialist in Assisted Reproduction. Sources Johnson, S. L., & Smith, G. D. (2023). Mitochondrial replacement in reproductive biology. Journal of Assisted Reproduction and Genetics, 40(2), 123-134. American Society for Reproductive Medicine. (2022). Practice Committee Opinion: Mitochondrial replacement. Fertility and Sterility, 117(5), 997-1005. MedlinePlus. (2024). In vitro fertilization. Retrieved from https://medlineplus.gov/ency/article/007333.htm National Institutes of Health. (2023). Stem cell research overview. Retrieved from https://www.nih.gov/research-training/stem-cell-research/stem-cell-faqs Remember that every story is unique. If you dream of becoming a parent, seeking the support of a fertility specialist is always the best decision. We are here to accompany you on this journey.

Irregular periods can be a warning sign for many women trying to conceive. While some variation in cycle length is normal, persistent irregularities may indicate causes of infertility in women that affect ovulation and reduce the chances of conceiving naturally. In this article, we will explore the causes of infertility in women related to irregular periods, the possible treatments available, and how IVF fertility treatment can be an effective solution. What Is Considered an Irregular Period? A regular menstrual cycle usually lasts between 21 and 35 days, with minor variations between cycles. However, periods are considered irregular when: If a woman frequently experiences irregular periods, it is crucial to visit an infertility clinic to receive an accurate diagnosis and determine whether there are causes of infertility in women that require treatment. Causes of Irregular Periods and Their Impact on Fertility Irregular periods are often linked to hormonal imbalances or medical conditions that affect ovulation. The most common causes of infertility in women with irregular cycles include: 1. Polycystic Ovary Syndrome (PCOS) Polycystic Ovary Syndrome (PCOS) is one of the leading causes of irregular periods and infertility. This hormonal disorder leads to excess androgen (male hormone) production, interfering with ovulation and causing menstrual irregularities. PCOS is strongly linked to ovarian causes of infertility, as the ovaries may produce multiple follicles without releasing a mature egg. Symptoms of PCOS: Irregular or absent menstrual cycles.Weight gain and insulin resistance.Acne or excessive hair growth. Treatment Options: Lifestyle changes, including diet and exercise.Medications such as Clomiphene Citrate or Letrozole to stimulate ovulation.IVF fertility treatment in more advanced cases. 2. Premature Ovarian Insufficiency (POI) Premature ovarian insufficiency (POI) occurs when the ovaries stop functioning properly before age 40. This leads to irregular periods or no menstruation due to reduced estrogen production and lack of ovulation. This condition is a clear example of ovarian causes of infertility and may be treated through ovarian stimulation or IVF fertility treatment at infertility clinics. 3. Thyroid Disorders Both hypothyroidism (low thyroid hormone production) and hyperthyroidism (excess thyroid hormones) can impact menstrual regularity. The thyroid plays a crucial role in hormone regulation, and imbalances can disrupt ovulation. 4. Chronic Stress and Extreme Weight Changes Chronic stress and extreme fluctuations in body weight can disrupt hormonal balance and halt ovulation. In these cases, stress reduction therapies and proper nutrition plans can help improve fertility. Diagnosing Irregular Periods and Infertility If a woman experiences irregular menstrual cycles and struggles to conceive, visiting an infertility clinic is the best approach for an accurate diagnosis. Common tests include:Hormone testing: Evaluating levels of FSH, LH, estrogen, progesterone, and thyroid hormones.Transvaginal ultrasound: Assessing the ovaries for cysts or abnormalities.Genetic testing: Especially in cases of premature ovarian insufficiency. Treatments for Infertility Caused by Irregular Periods Treatment options vary depending on the specific cause but commonly include: 1. Ovulation Induction Medications like Clomiphene Citrate or Letrozole can help stimulate ovulation in women with PCOS or mild ovulatory issues. 2. Intrauterine Insemination (IUI) This procedure may be helpful if ovulation can be induced with medication and the fallopian tubes are healthy. However, for more complex cases, IVF fertility treatment is usually recommended. 3. In Vitro Fertilization (IVF) IVF is one of the most effective treatments for women with irregular periods and ovulatory problems. In this process, eggs are retrieved and fertilized in a laboratory before being transferred to the uterus. Infertility clinics offering IVF fertility treatment can integrate advanced techniques like Intracytoplasmic Sperm Injection (ICSI), especially in cases of combined infertility factors, including male infertility. 4. Egg Donation For women with premature ovarian insufficiency, egg donation may be the best alternative within IVF fertility treatment. Conclusion Irregular periods can be an early indicator of causes of infertility in women, particularly when they disrupt ovulation. Identifying the issue early and visiting an infertility clinic is essential for receiving the appropriate treatment. If you have been trying to conceive without success and experience irregular menstrual cycles, IVF fertility treatment may offer the best chance of pregnancy. There are multiple options available to address ovarian causes of infertility, from medications to advanced assisted reproduction techniques.If you have concerns about your fertility, consult experts at infertility clinics and take control of your journey toward motherhood.