Science That Becomes Life At Ingenes, we are driven by one conviction: when science advances hand in hand with human care, more families achieve their dream of having a baby. Today, we share a milestone that fills us with pride: the first two babies conceived through the enhanced Endogen protocol using allogeneic mesenchymal stem cells from umbilical cord tissue, developed by Regen IVF, our innovation line in cellular therapies, in partnership with RenewTherapies and CryoHoldCo. This achievement not only validates years of clinical research but also opens the door for more patients to access the treatment at all our locations, removing the geographic barrier that existed when the protocol relied solely on autologous cells processed in Mexico City. From today, Endogen Stem Cells takes a firm step toward scalability, standardization, and safety, while keeping the language simple: restore the endometrium so it can be a “healthy little cradle” ready to receive the embryo under optimal conditions. What Is Endogen and What Is Its Goal? Endogen is a family of protocols created at Ingenes to improve endometrial quality. The endometrium is the inner layer of the uterus where the embryo implants and pregnancy develops. In assisted reproduction, specialists consider the endometrium suitable when it is trilaminar, homogeneous, and reaches ≥7 mm in thickness at the right time. Some patients do not achieve these conditions due to various causes (scar tissue, inflammation, suboptimal responses to preparation, etc.). Endogen addresses this challenge with two complementary strategies: In short: Endogen CM repopulates the natural stem cell “nursery” of the endometrium so the tissue functions as it should. Allogeneic Mesenchymal Stem Cells: Explained Simply Why can they be used between unrelated individuals?Mesenchymal stem cells do not express molecules that trigger immune rejection. Simply put: they do not raise the “rejection flag,” so the recipient’s body accepts them and uses them for repair. This immunomodulatory property is key to their safe use between unrelated patients. Advantages over autologous cells (from the patient herself): How Does Endogen CM Act on the Endometrium? The endometrium renews each menstrual cycle thanks to a stem cell niche in deep uterine layers. When this niche is damaged or diminished (e.g., Asherman’s syndrome, refractory thin endometrium), the tissue loses regenerative capacity. Endogen CM involves reintroducing mesenchymal stem cells into strategic uterine points to repopulate the niche. Expected effects include: The Clinical Procedure: Step by Step (Endogen CM) Partnerships That Enable Access Across All Locations RenewTherapies and CryoHoldCo provide donated umbilical cord mesenchymal stem cells, complying with the highest regulatory and quality standards. What changed? Previously, with autologous cells, patients had to travel to Ingenes in Mexico City on the exact day for collection, isolation, and application. Today, with allogeneic cells, the treatment comes to the patient. Quality, Safety, and Traceability: How We Ensure It Who Could Benefit from Endogen CM? Indications are determined after individual medical evaluation. In general, Endogen CM may be considered for: Important: Each case is studied multidisciplinarily, aiming to indicate the right therapy at the right time, maximizing benefit and safety. Can Endogen Be Combined with Techniques Like IVF MORE®? Yes, and it makes clinical sense. For patients needing improved egg quality (e.g., IVF MORE®), viable embryos, and a strategic transfer plan, Endogen CM completes the circle: optimizing the “little cradle” to receive that valuable embryo. Proper embryo + excellent endometrium = highest chances for pregnancy. Research and Publications The Endogen protocol with autologous cells already has published scientific evidence and has been highly cited internationally. The allogeneic protocol is under publication. These first births are part of the clinical series that our research team will include in the manuscript. Once published, this note will be updated with references. What This Breakthrough Means for Our Patients FAQ Can it be combined with FIV/IVF MORE®?Yes, and it is often recommended. Optimizing both embryo and endometrium increases the chances of achieving your baby.